Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A reciprocal interdependence between Nck and PI(4,5)P(2) promotes localized N-WASp-mediated actin polymerization in living cells.

Molecular cell - 13 Nov 2009

Rivera Gonzalo M, Vasilescu Dan, Papayannopoulos Venizelos, Lim Wendell A, Mayer Bruce J

Abstract excerpt

Modulation of actin dynamics through the N-WASp/Arp2/3 pathway is important in cell locomotion, membrane trafficking, and pathogen infection. Here, we demonstrate that Nck is essential for actin remodeling stimulated by phosphatidylinositol 4,5 bisphosphate (PI(4,5)P(2)) and, conversely, that PI(...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, CD7
Share to Cytoskeleton
Share to NIH 3T3 Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Oncogene Proteins

Share to Phosphatidylinositol 4,5-Diphosphate

Share to Phosphotransferases (Alcohol Group Acceptor)

Share to Receptors, IgG

Share to src Homology Domains

Source

Open in PubMed Open full text

Identifiers

PMID: 19917259
DOI: 10.1016/j.molcel.2009.10.025
PMCID: PMC2793683

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19917259-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A reciprocal interdependence between Nck and PI(4,5)P(2) promotes localized N-WASp-mediated actin polymerization in living cells.PMID 19917259Read ↗

WIP Provides an Essential Link between Nck and N-WASP during Arp2/3-Dependent Actin PolymerizationSemantic proximity Read ↗

Branching out in different directions: Emerging cellular functions for the Arp2/3 complex and WASP-family actin nucleation factorsSemantic proximity Read ↗

The adapter protein Nck: Role of individual SH3 and SH2 binding modules for protein interactions in T lymphocytesSemantic proximity Read ↗

Formation of a WIP-, WASp-, actin-, and myosin IIA–containing multiprotein complex in activated NK cells and its alteration by KIR inhibitory signalingSemantic proximity Read ↗

ARPC5 Isoforms and Their Regulation by Calcium-Calmodulin-N-WASP Drive Distinct Arp2/3-dependent Actin Remodeling Events in CD4 T CellsSemantic proximity Read ↗

IL-2 induces a WAVE2-dependent pathway for actin reorganization that enables WASp-independent human NK cell functionSemantic proximity Read ↗

WASH has a critical role in NK cell cytotoxicity through Lck-mediated phosphorylation.Semantic proximity Read ↗

Mechanism of actin network attachment to moving membranes: barbed end capture by N-WASP WH2 domains.Semantic proximity Read ↗

Role of Phosphoinositides in Cellular Signaling, Functions and DiseasesSemantic proximity Read ↗

N-WASP, a novel actin-depolymerizing protein, regulates the cortical cytoskeletal rearrangement in a PIP2-dependent manner downstream of tyrosine kinases.Semantic proximity Read ↗

Signalling to actin assembly via the WASP (Wiskott-Aldrich syndrome protein)-family proteins and the Arp2/3 complexSemantic proximity Read ↗

Phosphatidic acid regulation of PIPKI is critical for actin cytoskeletal reorganization.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.