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Article

Clustering of VASP actively drives processive, WH2 domain-mediated actin filament elongation.

The EMBO journal - 19 Nov 2008

Breitsprecher Dennis, Kiesewetter Antje K, Linkner Joern, Urbanke Claus, Resch Guenter P, Small J Victor, Faix Jan

Abstract excerpt

Vasodilator-stimulated phosphoprotein (VASP) is a key regulator of dynamic actin structures like filopodia and lamellipodia, but its precise function in their formation is controversial. Using in vitro TIRF microscopy, we show for the first time that both human and Dictyostelium VASP are directly involved in accelerating filament elongation by delivering monomeric actin to the growing barbed end. In solution,...

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Source

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Identifiers

PMID: 18923426
DOI: 10.1038/emboj.2008.211
PMCID: PMC2585163

Genes

VASP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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