Article
A complex of N-WASP and WIP integrates signalling cascades that lead to actin polymerization.
Nature cell biology - 1 Jul 2000
Moreau V, Frischknecht F, Reckmann I, Vincentelli R, Rabut G, Stewart D, Way M
Abstract excerpt
Wiskott-Aldrich syndrome protein (WASP) and N-WASP have emerged as key proteins connecting signalling cascades to actin polymerization. Here we show that the amino-terminal WH1 domain, and not the polyproline-rich region, of N-WASP is responsible for its recruitment to sites of actin polymerization during Cdc42-independent, actin-based motility of vaccinia virus. Recruitment of N-WASP to vaccinia is mediated by...
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