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Article

WASH and WAVE actin regulators of the Wiskott-Aldrich syndrome protein (WASP) family are controlled by analogous structurally related complexes.

Proceedings of the National Academy of Sciences of the United States of America - 8 Jun 2010

Jia Da, Gomez Timothy S, Metlagel Zoltan, Umetani Junko, Otwinowski Zbyszek, Rosen Michael K, Billadeau Daniel D

Abstract excerpt

We recently showed that the Wiskott-Aldrich syndrome protein (WASP) family member, WASH, localizes to endosomal subdomains and regulates endocytic vesicle scission in an Arp2/3-dependent manner. Mechanisms regulating WASH activity are unknown. Here we show that WASH functions in cells within a 500 kDa core complex containing Strumpellin, FAM21, KIAA1033 (SWIP), and CCDC53. Although recombinant WASH is...

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Identifiers

PMID: 20498093
DOI: 10.1073/pnas.0913293107
PMCID: PMC2890800

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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WASH and WAVE actin regulators of the Wiskott-Aldrich syndrome protein (WASP) family are controlled by analogous structurally related complexes.PMID 20498093Read ↗

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WASP family proteins: Molecular mechanisms and implications in human diseaseSemantic proximity Read ↗

The WASP and WAVE family proteinsSemantic proximity Read ↗

Drosophila WASH is required for integrin-mediated cell adhesion, cell motility and lysosomal neutralization.Semantic proximity Read ↗

Signalling to actin assembly via the WASP (Wiskott-Aldrich syndrome protein)-family proteins and the Arp2/3 complexSemantic proximity Read ↗

Multiple repeat elements within the FAM21 tail link the WASH actin regulatory complex to the retromer.Semantic proximity Read ↗

WHIMP links the actin nucleation machinery to Src-family kinase signaling during protrusion and motilitySemantic proximity Read ↗

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