Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Perlecan, a candidate gene for the CAPB locus, regulates prostate cancer cell growth via the Sonic Hedgehog pathway

1 Mar 2006

Abstract excerpt

BACKGROUND: Genetic studies associated the CAPB locus with familial risk of brain and prostate cancers. We have identified HSPG2 (Perlecan) as a candidate gene for CAPB. Previously we have linked Perlecan to Hedgehog signaling in Drosophila. More recently, we have demonstrated the importance of Hedgehog signaling in humans for advanced prostate cancer. RESULTS: Here we demonstrate Perlecan expression in prostate...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hedgehog Signaling Pathway Studies
Share to Prostate Cancer Diagnosis and Treatment
Share to Prostate Cancer Treatment and Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 16507112
DOI: 10.1186/1476-4598-5-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Perlecan, a candidate gene for the CAPB locus, regulates prostate cancer cell growth via the Sonic Hedgehog pathwayPMID 16507112Read ↗

Hedgehog pathway activity in the LADY prostate tumor modelSemantic proximity Read ↗

HOXB13 mutations and binding partners in prostate development and cancer: Function, clinical significance, and future directionsSemantic proximity Read ↗

Activation of the hedgehog pathway in advanced prostate cancerSemantic proximity Read ↗

Prostatic intraepithelial neoplasia and adenocarcinoma in mice expressing a probasin- Neu oncogenic transgeneSemantic proximity Read ↗

Developmental and androgenic regulation of chromatin regulators EZH2 and ANCCA/ATAD2 in the prostate Via MLL histone methylase complexSemantic proximity Read ↗

Gene expression signature of benign prostatic hyperplasia revealed by cDNA microarray analysisSemantic proximity Read ↗

Hedgehog signaling is active in human prostate cancer stroma and regulates proliferation and differentiation of adjacent epitheliumSemantic proximity Read ↗

Role of GLI2 transcription factor in growth and tumorigenicity of prostate cells.Semantic proximity Read ↗

HOXC8 Inhibits Androgen Receptor Signaling in Human Prostate Cancer Cells by Inhibiting SRC-3 Recruitment to Direct Androgen Target GenesSemantic proximity Read ↗

SCRIB expression is deregulated in human prostate cancer, and its deficiency in mice promotes prostate neoplasia.Semantic proximity Read ↗

A mouse prostate cancer model induced by Hedgehog overexpression.Semantic proximity Read ↗

Androgen-dependent prostate epithelial cell selection by targeting ARR(2)PBneo to the LPB-Tag model of prostate cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.