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Article

Role of GLI2 transcription factor in growth and tumorigenicity of prostate cells.

Cancer research - 15 Nov 2007

Thiyagarajan Saravanan, Bhatia Neehar, Reagan-Shaw Shannon, Cozma Diana, Thomas-Tikhonenko Andrei, Ahmad Nihal, Spiegelman Vladimir S

Abstract excerpt

Aberrant activation of the Hedgehog (Hh) signaling pathway has been reported in various cancer types including prostate cancer. The GLI2 transcription factor is a primary mediator of Hh signaling. However, its relative contribution to development of prostate tumors is poorly understood. To establish the role of GLI2 in maintaining the tumorigenic properties of prostate cancer cells, we developed GLI2-specific...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18006803
DOI: 10.1158/0008-5472.CAN-07-2015
PMCID: PMC2653855

Genes

GLI2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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