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Article

A mouse prostate cancer model induced by Hedgehog overexpression.

Journal of biomedical science - 1 May 2006

Chen Bo-Yie, Lin David Pei-Cheng, Liu Jer-Yuh, Chang Han, Huang Po-Hsuan, Chen Yie-Ling, Chang Han-Hsin

Abstract excerpt

Hedgehog is a regulatory protein during embryonic development and its abnormal activation in adult tissues has been implicated in tumorigenesis within sites where epithelial-mesenchymal interactions take place. In the prostate, Hedgehog signaling activation was observed during advanced cancer progression and metastasis, but whether Hedgehog overexpression can initiate prostate tumorigenesis remains unknown. We...

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PMID: 16374524
DOI: 10.1007/s11373-005-9050-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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