Hedgehog-EGFR cooperation response genes determine the oncogenic phenotype of basal cell carcinoma and tumour-initiating pancreatic cancer cells.

doi:10.1002/emmm.201100201

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Article

Hedgehog-EGFR cooperation response genes determine the oncogenic phenotype of basal cell carcinoma and tumour-initiating pancreatic cancer cells.

EMBO molecular medicine - 1 Mar 2012

Eberl Markus, Klingler Stefan, Mangelberger Doris, Loipetzberger Andrea, Damhofer Helene, Zoidl Kerstin, Schnidar Harald, Hache Hendrik, Bauer Hans-Christian, Solca Flavio, Hauser-Kronberger Cornelia, Ermilov Alexandre N, Verhaegen Monique E, Bichakjian Christopher K, Dlugosz Andrzej A, Nietfeld Wilfried, Sibilia Maria, Lehrach Hans, Wierling Christoph, Aberger Fritz

Abstract excerpt

Inhibition of Hedgehog (HH)/GLI signalling in cancer is a promising therapeutic approach. Interactions between HH/GLI and other oncogenic pathways affect the strength and tumourigenicity of HH/GLI. Cooperation of HH/GLI with epidermal growth factor receptor (EGFR) signalling promotes transformation and cancer cell proliferation in vitro. However, the in vivo relevance of HH-EGFR signal integration and the...

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Identifiers

PMID: 22294553
DOI: 10.1002/emmm.201100201
PMCID: PMC3305999

Genes

EGFR
CXCR4
FGF19
JUN
SOX2
SOX9

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