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Article

Hedgehog inhibition prolongs survival in a genetically engineered mouse model of pancreatic cancer

30 May 2008

Abstract excerpt

BACKGROUND AND AIMS: Pancreatic cancer is among the most dismal of human malignancies. Current therapeutic strategies are virtually ineffective in controlling advanced, metastatic disease. Recent evidence suggests that the Hedgehog signalling pathway is aberrantly reactivated in the majority of pancreatic cancers, and that Hedgehog blockade has the potential to prevent disease progression and metastatic spread....

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PMID: 18515410
DOI: 10.1136/gut.2007.148189

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