Article
Testing for association based on excess allele sharing in a sample of related cases and controls.
Human genetics - 1 Jun 2007
Klei Lambertus, Roeder Kathyrn
Abstract excerpt
Samples consisting of a mix of unrelated cases and controls, small pedigrees, and much larger pedigrees present a unique challenge for association studies. Few methods are available for efficient analysis of such a broad spectrum of data structures. In this paper we introduce a new matching statistic that is well suited to complex data structures and compare it with frequency-based methods available in the...
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