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Article

Dysfunction of Golgi tethers, SNAREs, and SNAPs in monocrotaline-induced pulmonary hypertension.

American journal of physiology. Lung cellular and molecular physiology - 1 Jun 2007

Sehgal Pravin B, Mukhopadhyay Somshuvra, Xu Fang, Patel Kirit, Shah Mehul

Abstract excerpt

Monocrotaline (MCT)-induced pulmonary hypertension (PH) in the rat is a widely used experimental model. We have previously shown that MCT pyrrole (MCTP) produces loss of caveolin-1 (cav-1) and endothelial nitric oxide synthase from plasma membrane raft microdomains in pulmonary arterial endothelial cells (PAEC) with the trapping of these proteins in the Golgi organelle (the Golgi blockade hypothesis). In the...

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Source

Identifiers

PMID: 17337506
DOI: 10.1152/ajplung.00463.2006

Genes

NSF
SNAP23

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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