Article

Palmitoylation regulates norepinephrine transporter trafficking and expression and is potentially involved in the pathogenesis of postural orthostatic tachycardia syndrome

2024-03-27

Abstract excerpt

<h4>ABSTRACT</h4> Postural orthostatic tachycardia syndrome (POTS) is an adrenergic signaling disorder characterized by excessive plasma norepinephrine, postural tachycardia, and syncope. The norepinephrine transporter (NET) modulates adrenergic homeostasis via reuptake of extracellular catecholamines and is implicated in the pathogenesis of adrenergic and neurological disorders. Previous research has outlined t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0317ce4f-45f7-54cd-b284-1c2301398287
DOI: 10.1101/2024.03.22.586171

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Palmitoylation regulates norepinephrine transporter trafficking and expression and is potentially involved in the pathogenesis of postural orthostatic tachycardia syndromeDOI 10.1101/2024.03.22.586171Read

A mutation in the human norepinephrine transporter gene (SLC6A2) associated with orthostatic intolerance disrupts surface expression of mutant and wild-type transporters.Semantic proximity Read

Single nucleotide polymorphisms in the human norepinephrine transporter gene affect expression, trafficking, antidepressant interaction, and protein kinase C regulation.Semantic proximity Read

Epigenetic Modification of the Norepinephrine Transporter Gene in Postural Tachycardia SyndromeSemantic proximity Read

Memory and synaptic deficits in <i>Hip14/DHHC17</i> knockout miceSemantic proximity Read

Determinants within the C-terminus of the human norepinephrine transporter dictate transporter trafficking, stability, and activity.Semantic proximity Read

Modulation of autism-associated serotonin transporters by palmitoylation: Insights into the molecular pathogenesis and targeted therapies for autism spectrum disorderSemantic proximity Read

Norepinephrine transporter defects lead to sympathetic hyperactivity in Familial Dysautonomia models.Semantic proximity Read

DHHC7-mediated palmitoylation of the accessory protein barttin critically regulates the functions of ClC-K chloride channels.Semantic proximity Read

DHHC5 protein palmitoylates flotillin-2 and is rapidly degraded on induction of neuronal differentiation in cultured cells.Semantic proximity Read

Norepinephrine deficiency is caused by combined abnormal mRNA processing and defective protein trafficking of dopamine beta-hydroxylase.Semantic proximity Read

S-Palmitoylation-Dependent Regulation of Cardiomyocyte Rac1 Signaling Activity and Cardiac HypertrophySemantic proximity Read

Genetic basis of clinical catecholamine disorders.Semantic proximity Read