Article
Monocrotaline Induces Endothelial Injury and Pulmonary Hypertension by Targeting the Extracellular Calcium-Sensing Receptor.
Journal of the American Heart Association - 22 Mar 2017
Xiao Rui, Su Yuan, Feng Tian, Sun Mengxiang, Liu Bingxun, Zhang Jiwei, Lu Yankai, Li Jiansha, Wang Tao, Zhu Liping, Hu Qinghua
Abstract excerpt
BACKGROUND: Monocrotaline has been widely used to establish an animal model of pulmonary hypertension. The molecular target underlying monocrotaline-induced pulmonary artery endothelial injury and pulmonary hypertension remains unknown. The extracellular calcium-sensing receptor (CaSR) and particularly its extracellular domain hold the potential structural basis for monocrotaline to bind. This study aimed to...
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