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Article

Dysfunctional intracellular trafficking in the pathobiology of pulmonary arterial hypertension.

American journal of respiratory cell and molecular biology - 1 Jul 2007

Sehgal Pravin B, Mukhopadhyay Somshuvra

Abstract excerpt

Discussions of the initiation of pulmonary arterial hypertension (PAH) in man and in experimental models have centered around intimal and medial proliferation in medium-sized pulmonary arteries. The histologic events are thought to include disordered proliferation of enlarged, vacuolated endothelial cells, neo-muscularization of the affected blood vessels, and vascular pruning. The discovery of the association of...

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Topics

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Share to Biological Transport
Share to Bone Morphogenetic Protein Receptors, Type II

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endothelium, Vascular

Share to Golgi Apparatus

Share to Hypertension, Pulmonary

Share to Hypoxia

Share to Microscopy, Electron

Share to Pulmonary Artery

Source

Open in PubMed Open full text

Identifiers

PMID: 17363775
DOI: 10.1165/rcmb.2007-0066TR
PMCID: PMC1899345

Genes

PAH
BMPR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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