Article
Palmitoylation of inducible nitric-oxide synthase at Cys-3 is required for proper intracellular traffic and nitric oxide synthesis.
The Journal of biological chemistry - 31 Dec 2004
Navarro-Lérida Inmaculada, Corvi Maria Martha, Barrientos Alberto Alvarez, Gavilanes Francisco, Berthiaume Luc Gérard, Rodríguez-Crespo Ignacio
Abstract excerpt
A number of cell types express inducible nitric-oxide synthase (NOS2) in response to exogenous insults such as bacterial lipopolysaccharide or proinflammatory cytokines. Although it has been known for some time that the N-terminal end of NOS2 suffers a post-translational modification, its exact identification has remained elusive. Using radioactive fatty acids, we show herein that NOS2 becomes thioacylated at...
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