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Article

Peroxynitrite donor SIN-1 alters high-affinity choline transporter activity by modifying its intracellular trafficking.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 18 Apr 2012

Cuddy Leah K, Gordon Alexis C, Black Stefanie A G, Jaworski Ewa, Ferguson Stephen S G, Rylett R Jane

Abstract excerpt

Sodium-coupled, high-affinity choline transporters (CHTs) are inhibited by 3-morpholinosydnonimine (SIN-1) [peroxynitrite (ONOO⁻) donor]; ONOO⁻ can be produced from nitric oxide and reactive oxygen species during neurodegeneration. SIN-1 rapidly increases CHT internalization from the cell surface, and this correlates with decreased choline uptake. This study addresses mechanisms by which SIN-1 inhibits CHT...

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Identifiers

PMID: 22514319
DOI: 10.1523/JNEUROSCI.5235-11.2012
PMCID: PMC6703479

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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