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Article

Mammalian cell expression of an active site mutant of Pseudomonas exotoxin disrupts LRP1 maturation.

Journal of biomedical science - 1 Jul 2008

Pastrana Diana V, Yun Cheol H, McKee Marian L, Fitzgerald David J

Abstract excerpt

Low density lipoprotein receptor-related protein 1, (LRP1) is a large multifunctional receptor that binds more than 25 physiologic ligands. In addition, it functions as the surface receptor for several Rhinoviruses, HIV-tat and Pseudomonas exotoxin (PE). We report that the expression of PE within mammalian cells can serve as a probe of LRP1 maturation and functionality. To avoid cell killing, an enzymatically...

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Source

Identifiers

PMID: 18351442
DOI: 10.1007/s11373-008-9245-z

Genes

LRP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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