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Article

Transplacental and transgeneration carcinogenic effect of 7,12-dimethylbenz[a]anthracene: relationship with ras oncogene activation.

Carcinogenesis - 1 Jan 1992

Loktionov A, Popovich I, Zabezhinski M, Martel N, Yamasaki H, Tomatis L

Abstract excerpt

Transgeneration transmission of the carcinogenic action of 7,12-dimethylbenz[a]anthracene (DMBA) was studied in two generations of mice using transplacental DMBA initiation followed by postnatal skin tumor promotion with 12-O-tetradecanoylphorbol-13-acetate (TPA) in the first generation (F0) and only promotion in the second generation (F1). Local application of TPA resulted in increased skin tumor yield in both...

Topics

9,10-Dimethyl-1,2-benzanthracene
Animals
Female
Fetus
Gene Expression Regulation
Genes, ras
Lung Neoplasms
Male
Mice
Mutation
Neoplasms, Experimental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pregnancy

Skin Neoplasms

Tetradecanoylphorbol Acetate

Source

Identifiers

PMID: 1733568
DOI: 10.1093/carcin/13.1.19

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1733568-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Transplacental and transgeneration carcinogenic effect of 7,12-dimethylbenz[a]anthracene: relationship with ras oncogene activation.PMID 1733568Read ↗

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