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Skin tumorigenesis and Ki-ras and Ha-ras mutations in tumors from adult mice exposed in utero to 3'-azido-2',3'-dideoxythymidine.

Molecular carcinogenesis - 1 Sept 1998

Zhang Z, Diwan B A, Anderson L M, Logsdon D, Olivero O A, Haines D C, Rice J M, Yuspa S H, Poirier M C

Abstract excerpt

This study was designed to evaluate the potential initiating effects of transplacental 3'-azido-2',3'-dideoxythymine (AZT) and the role of ras mutational activation in skin tumors induced in a two-stage mouse skin model. In addition, mouse liver and lung tumors from a transplacental AZT tumorigenicity study reported elsewhere (Olivero et al., J Natl Cancer Inst 89:1602-1608, 1997) were examined for evidence of...

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PMID: 9766437

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