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Article

Comparison of ras activation during epidermal carcinogenesis in vitro and in vivo.

Carcinogenesis - 1 Oct 1991

Quintanilla M, Haddow S, Jonas D, Jaffe D, Bowden G T, Balmain A

Abstract excerpt

Mouse epidermal cells have frequently been used to study the role of ras oncogenes in transformation in vivo and in vitro. After initiation with dimethylbenzanthracene (DMBA) in vivo, greater than 90% of the papillomas arising show the same A:T----T:A transversion at codon 61 of the H-ras gene, presumed to be the initiating event. On the other hand, initiation of epidermal cells in culture with carcinogens,...

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Source

Identifiers

PMID: 1934268
DOI: 10.1093/carcin/12.10.1875

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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