Comparison of ras activation during epidermal carcinogenesis in vitro and in vivo.

doi:10.1093/carcin/12.10.1875

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Article

Comparison of ras activation during epidermal carcinogenesis in vitro and in vivo.

Carcinogenesis - 1 Oct 1991

Quintanilla M, Haddow S, Jonas D, Jaffe D, Bowden G T, Balmain A

Abstract excerpt

Mouse epidermal cells have frequently been used to study the role of ras oncogenes in transformation in vivo and in vitro. After initiation with dimethylbenzanthracene (DMBA) in vivo, greater than 90% of the papillomas arising show the same A:T----T:A transversion at codon 61 of the H-ras gene, p...

Topics

9,10-Dimethyl-1,2-benzanthracene
Animals
Calcium
Carcinoma, Squamous Cell
Cell Line
Cell Line, Transformed
Cell Transformation, Neoplastic
Culture Media
Gene Expression Regulation, Neoplastic
Genes, ras
Humans
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred BALB C

Mice, Nude

Mutation

Neoplasm Transplantation

Papilloma

Skin Neoplasms

Source

Open in PubMed

Identifiers

PMID: 1934268
DOI: 10.1093/carcin/12.10.1875

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1934268-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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