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Article

Genetic basis of individual differences in the response to small-molecule drugs in yeast.

Nature genetics - 1 Apr 2007

Perlstein Ethan O, Ruderfer Douglas M, Roberts David C, Schreiber Stuart L, Kruglyak Leonid

Abstract excerpt

Individual response to small-molecule drugs is variable; a drug that provides a cure for some may confer no therapeutic benefit or trigger an adverse reaction in others. To begin to understand such differences systematically, we treated 104 genotyped segregants from a cross between two yeast strains with a collection of 100 diverse small molecules. We used linkage analysis to identify 124 distinct linkages...

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PMID: 17334364
DOI: 10.1038/ng1991

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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