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Article

Identifying Loci Contributing to Natural Variation in Xenobiotic Resistance in Drosophila.

PLoS genetics - 1 Nov 2015

Najarro Michael A, Hackett Jennifer L, Smith Brittny R, Highfill Chad A, King Elizabeth G, Long Anthony D, Macdonald Stuart J

Abstract excerpt

Natural populations exhibit a great deal of interindividual genetic variation in the response to toxins, exemplified by the variable clinical efficacy of pharmaceutical drugs in humans, and the evolution of pesticide resistant insects. Such variation can result from several phenomena, including variable metabolic detoxification of the xenobiotic, and differential sensitivity of the molecular target of the toxin....

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PMID: 26619284
DOI: 10.1371/journal.pgen.1005663
PMCID: PMC4664282

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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