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Article

Population-scale chemical response revealed by a barcoded yeast collection.

Nature communications - 28 May 2026

Dutta Abhishek, Garin Marion, Loegler Victor, Brach Gauthier, Friedrich Anne, Yoshimura Mami, Hirano Hiroyuki, Osada Hiroyuki, Boone Charles, Yashiroda Yoko, Hou Jing, Schacherer Joseph

Abstract excerpt

Natural genetic variation shapes how microbial populations adapt to environmental and chemical challenges, but scalable approaches to map genotype-phenotype relationships across diverse genetic backgrounds remain limited. Here, we developed a systematically barcoded collection of 520 Saccharomyces cerevisiae natural isolates that captures the ecological, geographical and genetic diversity of the species. Using...

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Identifiers

PMID: 42209485
DOI: 10.1038/s41467-026-73532-z
PMCID: PMC13389157

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