Revealing complex traits with small molecules and naturally recombinant yeast strains.

doi:10.1016/j.chembiol.2006.01.010

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Article

Revealing complex traits with small molecules and naturally recombinant yeast strains.

Chemistry & biology - 1 Mar 2006

Perlstein Ethan O, Ruderfer Douglas M, Ramachandran Gopal, Haggarty Stephen J, Kruglyak Leonid, Schreiber Stuart L

Abstract excerpt

Here we demonstrate that natural variants of the yeast Saccharomyces cerevisiae are a model system for the systematic study of complex traits, specifically the response to small molecules. As a complement to artificial knockout collections of S. cerevisiae widely used to study individual gene fun...

Topics

Biosensing Techniques
Chromosome Mapping
Gene Expression Regulation, Fungal
Mutation
Quantitative Trait Loci
Recombination, Genetic
Saccharomyces cerevisiae

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