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Article

Defining drug targets in yeast haploinsufficiency screens: application to human translational pharmacology.

Science signaling - 26 Aug 2008

Roberge Michel

Abstract excerpt

A major challenge in drug discovery is to identify the cellular targets responsible for the pharmacological activity of drug candidates. In the yeast Saccharomyces cerevisiae, a heterozygous diploid mutant collection of approximately 6000 strains, in each of which one copy of a single gene is deleted, is commercially available. With this collection, it is possible to evaluate the role of each gene product in the...

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PMID: 18728306
DOI: 10.1126/scisignal.134pt5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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