Article
TDP-43 immunoreactivity in neuronal inclusions in familial amyotrophic lateral sclerosis with or without SOD1 gene mutation.
Acta neuropathologica - 1 May 2007
Tan Chun-Feng, Eguchi Hiroto, Tagawa Asako, Onodera Osamu, Iwasaki Takuya, Tsujino Akira, Nishizawa Masatoyo, Kakita Akiyoshi, Takahashi Hitoshi
Abstract excerpt
Recently, 43-kDa TAR DNA-binding protein (TDP-43) was identified as a component of ubiquitinated inclusions (UIs) in sporadic amyotrophic lateral sclerosis (SALS). To clarify whether TDP-43 immunoreactivity is present in neuronal inclusions in familial ALS (FALS), we examined immunohistochemically the brains and spinal cords from four cases of FALS, two with Cu/Zn superoxide dismutase (SOD1) gene mutation and two...
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