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Article

Pathological Modification of TDP-43 in Amyotrophic Lateral Sclerosis with SOD1 Mutations.

Molecular neurobiology - 1 Mar 2019

Jeon Gye Sun, Shim Yu-Mi, Lee Do-Yeon, Kim Jun-Soon, Kang MinJin, Ahn So Hyun, Shin Je-Young, Geum Dongho, Hong Yoon Ho, Sung Jung-Joon

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a fatal, adult-onset, progressive neurodegenerative disorder with no known cure. Cu/Zn-superoxide dismutase (SOD1) was the first identified protein associated with familial ALS (fALS). Recently, TAR DNA-binding protein 43 (TDP-43) has been found to be a principal component of ubiquitinated cytoplasmic inclusions in neurons and glia in ALS. However, it remains unclear whether...

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Identifiers

PMID: 29982983
DOI: 10.1007/s12035-018-1218-2
PMCID: PMC6394608

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SOD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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