Article
Lack of TDP-43 abnormalities in mutant SOD1 transgenic mice shows disparity with ALS.
Neuroscience letters - 13 Jun 2007
Robertson Janice, Sanelli Teresa, Xiao Shangxi, Yang Wencheng, Horne Patrick, Hammond Robert, Pioro Erik P, Strong Michael J
Abstract excerpt
Mislocalization of the TAR-DNA binding protein (TDP-43) from the nucleus to the cytoplasm of diseased motor neurons and association with intraneuronal ubiquitinated inclusions has recently been reported in amyotrophic lateral sclerosis (ALS). Here, we have investigated TDP-43 immunoreactivity in...
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