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Article

Lack of TDP-43 abnormalities in mutant SOD1 transgenic mice shows disparity with ALS.

Neuroscience letters - 13 Jun 2007

Robertson Janice, Sanelli Teresa, Xiao Shangxi, Yang Wencheng, Horne Patrick, Hammond Robert, Pioro Erik P, Strong Michael J

Abstract excerpt

Mislocalization of the TAR-DNA binding protein (TDP-43) from the nucleus to the cytoplasm of diseased motor neurons and association with intraneuronal ubiquitinated inclusions has recently been reported in amyotrophic lateral sclerosis (ALS). Here, we have investigated TDP-43 immunoreactivity in three lines of mutant SOD1 transgenic mice, G93A, G37R and G85R and compared with labeling in one sporadic ALS case and...

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Source

Identifiers

PMID: 17543992
DOI: 10.1016/j.neulet.2007.03.066

Genes

SOD1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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