Article
Amyotrophic lateral sclerosis, frontotemporal dementia and beyond: the TDP-43 diseases.
Journal of neurology - 1 Aug 2009
Geser Felix, Martinez-Lage Maria, Kwong Linda K, Lee Virginia M-Y, Trojanowski John Q
Abstract excerpt
Ever since the significance of pathological 43-kDa transactivating responsive sequence DNA-binding protein (TDP-43) for human disease has been recognized in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with ubiquitin positive inclusions (FTLD-U), a number of publications have emerged reporting on this pathology in a variety of neurodegenerative diseases. Given the heterogeneous and,...
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