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Article

TDP-43 expression in mouse models of amyotrophic lateral sclerosis and spinal muscular atrophy

28 Oct 2008

Abstract excerpt

BACKGROUND: Redistribution of nuclear TAR DNA binding protein 43 (TDP-43) to the cytoplasm and ubiquitinated inclusions of spinal motor neurons and glial cells is characteristic of amyotrophic lateral sclerosis (ALS) pathology. Recent evidence suggests that TDP-43 pathology is common to sporadic ALS and familial ALS without SOD1 mutation, but not SOD1-related fALS cases. Furthermore, it remains unclear whether...

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PMID: 18957104
DOI: 10.1186/1471-2202-9-104

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