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Article

Specific vulnerability of iPSC-derived motor neurons with TDP-43 gene mutation to oxidative stress.

Molecular brain - 26 Jul 2023

Onda-Ohto Asako, Hasegawa-Ogawa Minami, Matsuno Hiromasa, Shiraishi Tomotaka, Bono Keiko, Hiraki Hiromi, Kanegae Yumi, Iguchi Yasuyuki, Okano Hirotaka James

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a disease that affects motor neurons and has a poor prognosis. We focused on TAR DNA-binding protein 43 kDa (TDP-43), which is a common component of neuronal inclusions in many ALS patients. To analyze the contribution of TDP-43 mutations to ALS in human cells, we first introduced TDP-43 mutations into healthy human iPSCs using CRISPR/Cas9 gene editing technology, induced...

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Identifiers

PMID: 37496071
DOI: 10.1186/s13041-023-01050-w
PMCID: PMC10369818

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