Article
Pathological TDP-43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with SOD1 mutations.
Annals of neurology - 1 May 2007
Mackenzie Ian R A, Bigio Eileen H, Ince Paul G, Geser Felix, Neumann Manuela, Cairns Nigel J, Kwong Linda K, Forman Mark S, Ravits John, Stewart Heather, Eisen Andrew, McClusky Leo, Kretzschmar Hans A, Monoranu Camelia M, Highley J Robin, Kirby Janine, Siddique Teepu, Shaw Pamela J, Lee Virginia M-Y, Trojanowski John Q
Abstract excerpt
OBJECTIVE: Amyotrophic lateral sclerosis (ALS) is a common, fatal motor neuron disorder with no effective treatment. Approximately 10% of cases are familial ALS (FALS), and the most common genetic abnormality is superoxide dismutase-1 (SOD1) mutations. Most ALS research in the past decade has foc...
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