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Article

TDP-43 Proteinopathies: Neurodegenerative Protein Misfolding Diseases without Amyloidosis

5 Dec 2007

Abstract excerpt

In this review, we summarize recent advances in understanding frontotemporal lobar degeneration (FTLD), amyotrophic lateral sclerosis (ALS) and related neurodegenerative disorders that are collectively known as TDP-43 proteinopathies, since transactive response DNA-binding protein 43 (TDP-43) was recently shown to be the major component of the ubiquitinated inclusions that are their pathological hallmarks. TDP-43...

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PMID: 18097159
DOI: 10.1159/000109758

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