Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

New classification of HLA-DRB1 alleles in rheumatoid arthritis susceptibility: a combined analysis of worldwide samples.

Arthritis research & therapy - 1 Jan 2008

Barnetche Thomas, Constantin Arnaud, Cantagrel Alain, Cambon-Thomsen Anne, Gourraud Pierre-Antoine

Abstract excerpt

INTRODUCTION: Rheumatoid arthritis (RA) is a complex polygenic disease of unknown etiology. HLA-DRB1 alleles encoding the shared epitope (SE) (RAA amino acid pattern in positions 72 to 74 of the third hypervariable region of the DRbeta1 chain) are associated with RA susceptibility. A new classification of HLA-DRB1 SE alleles has been developed by Tezenas du Montcel and colleagues to refine the association between...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adolescent
Share to Alleles

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Arthritis, Rheumatoid

Share to Heterozygote

Share to HLA-DR Antigens

Share to HLA-DRB1 Chains

Share to Racial Groups

Share to White People

Source

Open in PubMed Open full text

Identifiers

PMID: 18307784
DOI: 10.1186/ar2379
PMCID: PMC2374469

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

New classification of HLA-DRB1 alleles in rheumatoid arthritis susceptibility: a combined analysis of worldwide samples.PMID 18307784Read ↗

A new classification of HLA-DRB1 alleles differentiates predisposing and protective alleles for rheumatoid arthritis structural severity.Semantic proximity Read ↗

New classification of HLA-DRB1 alleles supports the shared epitope hypothesis of rheumatoid arthritis susceptibility.Semantic proximity Read ↗

A new classification of HLA-DRB1 alleles differentiates predisposing and protective alleles for autoantibody production in rheumatoid arthritis.Semantic proximity Read ↗

Rheumatoid arthritis association in Colombian population is restricted to HLA-DRB1*04 QRRAA alleles.Semantic proximity Read ↗

The Genetic Variants of HLA-DRB1 Alleles and the Chance of Developing Rheumatoid Arthritis: Systematic Review and meta-analysisSemantic proximity Read ↗

Advances in the genetics of rheumatoid arthritis point to subclassification into distinct disease subsets.Semantic proximity Read ↗

HLA-DRB1 shared epitope allele polymorphisms and rheumatoid arthritis: a systemic review and meta-analysis.Semantic proximity Read ↗

Current Understanding of an Emerging Role of HLA-DRB1 Gene in Rheumatoid Arthritis-From Research to Clinical Practice.Semantic proximity Read ↗

Reshaping the shared epitope hypothesis: HLA-associated risk for rheumatoid arthritis is encoded by amino acid substitutions at positions 67-74 of the HLA-DRB1 molecule.Semantic proximity Read ↗

Meta-analyses of the association of HLA-DRB1 alleles with rheumatoid arthritis among Arabs.Semantic proximity Read ↗

HLA-DRB1 allele association with rheumatoid arthritis susceptibility and severity in Syria.Semantic proximity Read ↗

Human leukocyte antigen polymorphisms and personalized medicine for rheumatoid arthritis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.