Article
A spectrum of susceptibility to rheumatoid arthritis within HLA-DRB1: stratification by autoantibody status in a large UK population.
Genes and immunity - 1 Feb 2012
Mackie S L, Taylor J C, Martin S G, Wordsworth P, Steer S, Wilson A G, Worthington J, Emery P, Barrett J H, Morgan A W
Abstract excerpt
Previously-proposed rheumatoid arthritis (RA) HLA-DRB1 susceptibility and protective models were compared, based on amino acids at positions 67-74 and autoantibody combinations. 3 657 RA patients and 1 357 controls were studied using logistic regression, with secondary stratification by anti-citrullinated peptide antibodies(ACPA) and rheumatoid factor(RF). Susceptibility models were based on previously defined...
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