Article
A new classification of HLA-DRB1 alleles differentiates predisposing and protective alleles for rheumatoid arthritis structural severity.
Arthritis and rheumatism - 1 Feb 2006
Gourraud Pierre-Antoine, Boyer Jean-Frédéric, Barnetche Thomas, Abbal Michel, Cambon-Thomsen Anne, Cantagrel Alain, Constantin Arnaud
Abstract excerpt
OBJECTIVE: A new classification of HLA-DRB1 alleles supporting the shared epitope hypothesis of rheumatoid arthritis (RA) susceptibility was recently introduced. We investigated the relevance of this classification in terms of the structural severity of RA. METHODS: The study group comprised 144 patients who were included in a prospective longitudinal cohort of French Caucasoid patients with early RA. Progression...
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