Article
HLA-DRB1 shared epitope-dependent DR-DQ haplotypes are associated with both anti-CCP-positive and -negative rheumatoid arthritis in Chinese Han.
PloS one - 1 Jan 2013
Liu Xu, Guo Jianping, Jia Yuan, Zhao Yi, Liu Xia, Cheng Feng, Li Xiaoxia, Zheng Yi, Shi Xuhua, Li Haiyun, Huang Cibo, Cheng Yongjing, Lai Bei, Huang Yanhong, Wang Tian, Ding Bo, Li Zhangguo
Abstract excerpt
The association between Human Leukocyte Antigen (HLA) class II and rheumatoid arthritis (RA) has been extensively studied, but few reported DR-DQ haplotype. Here we investigated the association of HLA-DRB1, DQA1, DQB1, and DR-DQ haplotypes with RA susceptibility and with anti-CCP antibodies in 281 RA patients and 297 control in Han population. High-resolution genotyping were performed. The HLA-DRB1 shared epitope...
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