Article
New classification of HLA-DRB1 alleles supports the shared epitope hypothesis of rheumatoid arthritis susceptibility.
Arthritis and rheumatism - 1 Apr 2005
du Montcel Sophie Tezenas, Michou Laetitia, Petit-Teixeira Elisabeth, Osorio José, Lemaire Isabelle, Lasbleiz Sandra, Pierlot Céline, Quillet Patrick, Bardin Thomas, Prum Bernard, Cornelis François, Clerget-Darpoux Françoise
Abstract excerpt
OBJECTIVE: The shared epitope hypothesis was formulated to explain the involvement of HLA-DRB1 in rheumatoid arthritis (RA). However, several studies, which considered only the HLA-DRB1 alleles shown to be associated with RA risk, rejected this hypothesis. In this report, we propose that a different classification of HLA-DRB1 alleles be considered, based on the amino acid sequence at position 70-74. METHODS: The...
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