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Article

Functional analysis of the hepatic HMG-CoA reductase promoter by in vivo electroporation.

Experimental biology and medicine (Maywood, N.J.) - 1 Mar 2007

Lagor William R, Heller Richard, de Groh Eric D, Ness Gene C

Abstract excerpt

HMG-CoA reductase (HMGR) catalyzes the rate-controlling step in cholesterol production. This enzyme is highly expressed in the liver, where it is subject to extensive hormonal and dietary regulation. Although much is known about the regulation of the HMGR promoter in cultured cells, this issue has not been directly addressed in liver. The technique of in vivo electroporation was utilized to perform the first...

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PMID: 17327468

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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