Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of insulin-responsive regions in the HMG-CoA reductase promoter.

Biochemical and biophysical research communications - 11 Jun 2004

Osborne Aaron R, Pollock Veronica V, Lagor William R, Ness Gene C

Abstract excerpt

An insulin-responsive line of rat hepatoma cells, H4IIE, was used to investigate the basis for insulin's transcriptional regulation of HMG-CoA reductase. Insulin addition to the media of these cells resulted in at least a 10-fold increase in levels of HMG-CoA reductase protein. Adding insulin to H4IIE cells transfected with pHMGR1 (containing the proximal reductase promoter from -270 to +20 ligated to luciferase)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cyclic AMP
Share to Genes, Reporter
Share to Hydroxymethylglutaryl CoA Reductases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Immunoblotting

Share to Insulin

Share to Luciferases

Share to Response Elements

Share to Transfection

Source

Identifiers

PMID: 15147943
DOI: 10.1016/j.bbrc.2004.04.105

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of insulin-responsive regions in the HMG-CoA reductase promoter.PMID 15147943Read ↗

Sterol Regulatory Element-Binding Protein-1 Mediates the Effect of Insulin on Hexokinase II Gene Expression in Human Muscle CellsSemantic proximity Read ↗

Identification of cis-elements mediating the stimulation of rat insulin-like growth factor-binding protein-1 promoter activity by dexamethasone, cyclic adenosine 3',5'-monophosphate, and phorbol esters, and inhibition by insulin.Semantic proximity Read ↗

Insulin activates human sterol-regulatory-element-binding protein-1c (SREBP-1c) promoter through SRE motifs.Semantic proximity Read ↗

The Insulin-like Growth Factor-binding Protein 1 Gene Is a Primary Target of Peroxisome Proliferator-activated ReceptorsSemantic proximity Read ↗

Transcriptional regulation of insulin receptor gene promoter in rat hepatocytes.Semantic proximity Read ↗

An insulin response element in the glyceraldehyde-3-phosphate dehydrogenase gene binds a nuclear protein induced by insulin in cultured cells and by nutritional manipulations in vivo.Semantic proximity Read ↗

Down-regulation of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene by insulin: the role of the forkhead transcription factor FKHRL1.Semantic proximity Read ↗

One of three CCArGG box/serum response elements of the beta-actin gene is an insulin-responsive element.Semantic proximity Read ↗

Cloning and Characterization of the Human Insulin-Like Growth Factor-I Receptor Gene 5′-Flanking RegionSemantic proximity Read ↗

Regulation of phosphoenolpyruvate carboxykinase gene expression by insulin. Use of the stable transfection approach to locate an insulin responsive sequence.Semantic proximity Read ↗

Structure and Function of a Human Insulin-like Growth Factor-I Gene PromoterSemantic proximity Read ↗

Hepatic nuclear factor 3 and high mobility group I/Y proteins bind the insulin response element of the insulin-like growth factor-binding protein-1 promoter.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.