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Article

Transcriptional regulation of the membrane-associated prostaglandin E2 synthase gene. Essential role of the transcription factor Egr-1.

The Journal of biological chemistry - 9 Aug 2002

Naraba Hiroaki, Yokoyama Chieko, Tago Naomi, Murakami Makoto, Kudo Ichiro, Fueki Mai, Oh-Ishi Sachiko, Tanabe Tadashi

Abstract excerpt

Membrane-associated prostaglandin (PG) E2 synthase (mPGES) is an inducible terminal enzyme in the biosynthetic pathway for prostaglandin E2, which participates in many biological processes. In this study, we investigated the molecular mechanism controlling the inducible expression of mPGES. The mouse mPGES gene consisted of three exons, and its 5'-proximal promoter contained consensus motifs for the binding of...

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PMID: 12034740
DOI: 10.1074/jbc.M203618200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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