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Article

Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a.

The Journal of clinical investigation - 1 Oct 1996

Shimano H, Horton J D, Hammer R E, Shimomura I, Brown M S, Goldstein J L

Abstract excerpt

The NH2-terminal domain of sterol-regulatory element binding protein-1a (SREBP-1a) activates transcription of genes encoding enzymes of cholesterol and fatty acid biosynthesis in cultured cells. This domain is synthesized as part of a membrane-bound precursor that is attached to the nuclear envelope and endoplasmic reticulum. In sterol-depleted cells a two-step proteolytic process releases this NH2-terminal...

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Identifiers

PMID: 8833906
DOI: 10.1172/JCI118951
PMCID: PMC507590

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Source receipt: pubmed, retrieved 7 Sept 2026.

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