Identification of nucleotides responsible for enhancer activity of sterol regulatory element in low density lipoprotein receptor gene.

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Article

Identification of nucleotides responsible for enhancer activity of sterol regulatory element in low density lipoprotein receptor gene.

The Journal of biological chemistry - 5 Feb 1990

Smith J R, Osborne T F, Goldstein J L, Brown M S

Abstract excerpt

Sterol-dependent regulation of the low density lipoprotein (LDL) receptor promoter has been localized previously to a 16-base pair sequence, designated repeat 2, in the 5'-flanking region of the gene. In the current study, we show that the central 10 nucleotides of repeat 2 are crucial for the sterol regulatory activity. This sequence includes an octamer, designated sterol regulatory element 1 (SRE-1), which was...

Topics

Animals
Base Composition
Cell Line
Chimera
Enhancer Elements, Genetic
Gene Expression Regulation
Genes
Genes, Regulator
Humans
Hydroxymethylglutaryl CoA Reductases
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Plasmids

Promoter Regions, Genetic

RNA, Messenger

Receptors, LDL

Restriction Mapping

Sterols

Transcription, Genetic

Source

Open in PubMed

Identifiers

PMID: 2298751

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2298751-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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