Article
In vivo functional characterization of the aldolase B gene enhancer.
The Journal of biological chemistry - 9 Aug 2002
Gregori Claudine, Porteu Arlette, Mitchell Claudia, Kahn Axel, Pichard Anne-Lise
Abstract excerpt
A 400-bp intronic enhancer fragment in conjunction with the proximal promoter of the aldolase B gene provided correct tissue-specific expression in transgenic mice together with hormonal regulation in the liver. We investigated in vivo and in cultured cells the contribution of the intronic regulatory sequences and their interaction with the promoter elements in controlling aldolase B gene expression. Transgene...
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