Article
Early embryonic lethality caused by targeted disruption of the 3-hydroxy-3-methylglutaryl-CoA reductase gene.
The Journal of biological chemistry - 31 Oct 2003
Ohashi Ken, Osuga Jun-ichi, Tozawa Ryuichi, Kitamine Tetsuya, Yagyu Hiroaki, Sekiya Motohiro, Tomita Sachiko, Okazaki Hiroaki, Tamura Yoshiaki, Yahagi Naoya, Iizuka Yoko, Harada Kenji, Gotoda Takanari, Shimano Hitoshi, Yamada Nobuhiro, Ishibashi Shun
Abstract excerpt
The endoplasmic reticulum (ER) enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, which converts HMG-CoA to mevalonate, catalyzes the ratelimiting step in cholesterol biosynthesis. Because this mevalonate pathway also produces several non-sterol isoprenoid compounds, the level of HMG-CoA reductase activity may coordinate many cellular processes and functions. We used gene targeting to knock out the...
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