Article
Estrogen receptor alpha gene polymorphisms associated with incident aging macula disorder.
Investigative ophthalmology & visual science - 1 Mar 2007
Boekhoorn Sharmila S, Vingerling Johannes R, Uitterlinden André G, Van Meurs Joyce B J, van Duijn Cornelia M, Pols Huibert A P, Hofman Albert, de Jong Paulus T V M
Abstract excerpt
PURPOSE: It has been suggested that early menopause increases the risk of aging-macula disorder (AMD), the major cause of incurable blindness with a dry and wet late subtype, and that exposure to endogenous or postmenopausal exogenous estrogens reduces this risk. This study was undertaken to investigate whether genetic variations in the estrogen receptor alpha (ESR1) gene are associated with incident AMD....
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