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Article

Population-based resequencing of ANGPTL4 uncovers variations that reduce triglycerides and increase HDL.

Nature genetics - 1 Apr 2007

Romeo Stefano, Pennacchio Len A, Fu Yunxin, Boerwinkle Eric, Tybjaerg-Hansen Anne, Hobbs Helen H, Cohen Jonathan C

Abstract excerpt

Resequencing genes provides the opportunity to assess the full spectrum of variants that influence complex traits. Here we report the first application of resequencing to a large population (n = 3,551) to examine the role of the adipokine ANGPTL4 in lipid metabolism. Nonsynonymous variants in ANGPTL4 were more prevalent in individuals with triglyceride levels in the lowest quartile than in individuals with levels...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17322881
DOI: 10.1038/ng1984
PMCID: PMC2762948

Genes

ANGPTL4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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