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ANGPTL8 protein-truncating variant associated with lower serum triglycerides and risk of coronary disease.

PLoS genetics - 1 Apr 2021

Helkkula Pyry, Kiiskinen Tuomo, Havulinna Aki S, Karjalainen Juha, Koskinen Seppo, Salomaa Veikko, Daly Mark J, Palotie Aarno, Surakka Ida, Ripatti Samuli

Abstract excerpt

Protein-truncating variants (PTVs) affecting dyslipidemia risk may point to therapeutic targets for cardiometabolic disease. Our objective was to identify PTVs that were associated with both lipid levels and the risk of coronary artery disease (CAD) or type 2 diabetes (T2D) and assess their possible associations with risks of other diseases. To achieve this aim, we leveraged the enrichment of PTVs in the Finnish...

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Angiopoietin-like Proteins
Coronary Artery Disease
Diabetes Mellitus, Type 2
Dyslipidemias
Hydroxymethylglutaryl-CoA Reductase Inhibitors

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PMID: 33909604
DOI: 10.1371/journal.pgen.1009501
PMCID: PMC8109807

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