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Article

Impact of loss-of-function in angiopoietin-like 4 on the human phenome.

Atherosclerosis - 1 Jun 2024

Gagnon Eloi, Bourgault Jérome, Gobeil Émilie, Thériault Sébastien, Arsenault Benoit J

Abstract excerpt

BACKGROUND: Carriers of the E40K loss-of-function variant in Angiopoietin-like 4 (ANGPTL4), have lower plasma triglyceride levels as well as lower rates of coronary artery disease (CAD) and type 2 diabetes (T2D). These genetic data suggest ANGPTL4 inhibition as a potential therapeutic target for cardiometabolic diseases. However, it is unknown whether the association between E40K and human diseases is due to...

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PMID: 38703417
DOI: 10.1016/j.atherosclerosis.2024.117558

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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