Article

Impact of loss-of-function in angiopoietin-like 4 on the human phenome

2024-02-14

Abstract excerpt

<h4>Background</h4> Carriers of the E40K loss-of-function variant in Angiopoietin-like 4 ( ANGPTL4 ), have lower plasma triglyceride levels as well as lower rates of coronary artery disease (CAD) and type 2 diabetes (T2D). These genetic data suggest ANGPTL4 inhibition as a potential therapeutic target for cardiometabolic diseases. However, it is unknown whether the association between E40K and human diseases is du...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2fac0ee5-4588-5ac0-bc68-fd1a4297aabc
DOI: 10.1101/2024.02.13.24302776

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Impact of loss-of-function in angiopoietin-like 4 on the human phenomeDOI 10.1101/2024.02.13.24302776Read

Impact of loss-of-function in angiopoietin-like 4 on the human phenome.Semantic proximity Read

Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes.Semantic proximity Read

Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease.Semantic proximity Read

Inactivating Variants in ANGPTL4 and Risk of Coronary Artery Disease.Semantic proximity Read

<i>ANGPTL8</i> protein-truncating variant and the risk of coronary disease, type 2 diabetes and adverse effectsSemantic proximity Read

Distribution and medical impact of loss-of-function variants in the Finnish founder population.Semantic proximity Read

ANGPTL4 E40K and T266M: effects on plasma triglyceride and HDL levels, postprandial responses, and CHD risk.Semantic proximity Read

ANGPTL8 protein-truncating variant associated with lower serum triglycerides and risk of coronary disease.Semantic proximity Read

Genetic inhibition of angiopoietin-like protein-3, lipids, and cardiometabolic riskSemantic proximity Read

Genetic inhibition of angiopoietin-like protein-3, lipoprotein-lipid levels and cardiometabolic diseasesSemantic proximity Read

Genetic Mimicry Analysis Reveals the Specific Lipases Targeted by the ANGPTL3-ANGPTL8 Complex and ANGPTL4Semantic proximity Read

Population-based resequencing of ANGPTL4 uncovers variations that reduce triglycerides and increase HDL.Semantic proximity Read